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Schotten–Baumann reaction
The Schotten–Baumann reaction is a method to synthesise amides from amines and acid chlorides:
Sometimes the name for this reaction is also used to indicate the reaction between an acid chloride and an alcohol to form an ester. The reaction was first described in 1883 by German chemists Carl Schotten and Eugen Baumann.〔W Pötsch. ''Lexikon bedeutender Chemiker'' (VEB Bibliographisches Institut Leipzig, 1989) (ISBN 3-323-00185-0)〕〔M B Smith, J March. ''March's Advanced Organic Chemistry'' (Wiley, 2001) (ISBN 0-471-58589-0)〕
== Reaction mechanism ==
In the first step an acid chloride reacts with an amine so that an amide is formed, together with a proton and a chloride ion. Addition of a base is required to absorb this acidic proton, or the reaction will not proceed. Often, an aqueous solution of a base is slowly added to the reaction mixture.
The name "Schotten–Baumann reaction conditions" is often used to indicate the use of a two-phase solvent system, consisting of water and an organic solvent. The base within the water phase neutralizes the acid, generated in the reaction, while the starting materials and product remain in the organic phase, often dichloromethane or diethyl ether. The presence of a base prevents the amine reactant from being protonated, which would make it unable to react as a nucleophile.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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